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Saberry-Amla

|Ayurveda products

 What is very interesting  in this company?  Are Ayurveda products (tea, toothpaste)  and  products based on Amla . Amla is a unique product of the Indian medicine. It is written in the ancient treatises that Amla is the plant the Gods talk to healing the ill ones. Amla is also called Amalaki or just  the Indian gooseberry. In India they make  therapeutic jam from it called Chavanprash, hair oil, revitalizing powders Churnas. It’s a strong antioxidant Rassayana, an elixir of youth,a  rich source of  vitamin C in nature.

       
 It  improves the immunity, prevents premature aging, normalizes all the body activites,  has anti-inflammatory, anti-virus, antiseptic and regenerating properties. It also improves the blood circulation, the composition of blood, cleans the blood, increases hemoglobin, reduces cholesterol, improves the eyesight, strengthens the memory , heart, nervous system, bones, promotes hair growth, prevents hair loss and gray hair, eliminates dandruff.

But for those who hasn’t been to India it should be mentioned how the raw materials are collected, and how revitalizing products are produced and issued. The compositions of preparations are mostly vegetable. All the components depending on the direction of action are collected at a certain time , on a certain lunar day, afterwards the compositions are mixed and the ritual of praying and saying mantras is done by monks and Brahmans, i.e. these products are therapeutic not only for the physical but for energy health too.

The next very interesting product - is water filter on graphene made by the academician Petrik. I want to suggest your watching the video where you can see how Cola is cleaned to the state of clean and healthy water and the same with oil.

About Saberry:

Saberry® is a proprietary, patent pending, extract of fruits of Emblica officinalis. (synonymous with Phyllanthus emblica), more commonly known as Amla.

Saberry® is a light colored powder and is processed from carefully chosen, fresh Amla by a novel process, to retain the natural goodness of the fruits.

Saberry® from Sabinsa Corporation is standardized to contain a minimum of 10% β‐glucogallin and 50% gallates. Saberry® is the result of efforts to prepare an authenticated Amla extract, standardized using a valid biomarker, β-glucogallin. In‐house studies revealed that β-glucogallin is a more powerful antioxidant molecule, as compared to ascorbic acid.

Amla in the Ayurvedic tradition:

Amla fruits are regarded as an adaptogen. The term 'adaptogen' is used by herbalists to refer to a natural product that potentially increases the body's resistance to stress, trauma, anxiety and fatigue.

Amla is considered to be a "rasayana" herb in Ayurveda. According to ayurvedic texts, "rasayana" is generally used to rejuvenate the general health of the body, or aims at enabling the body's maximum potential.

Traditional Uses of Amla:
In India, the fruit is pickled with salt, oil, and spices, and also converted into jams and preserves. It is used as a primary ingredient in the ayurvedic rasayana tonic "Chyawanprash", and in the herbal composition "Triphala" where it is mixed with chebulic and beleric myrobalans.

The Science behind Saberry® :

The fruits of Emblica officinalis have been reported to contain low molecular weight hydrolysable tannins-emblicanin A and emblicanin B, along with pedunculagin and punigluconin. Low levels of β-glucogallin and other mucic acid gallates have also been reported in aqueous extracts of Emblica officinalis fruits. The fruits of Amla have also been considered rich in vitamin C content.

In 2006, Scartezzini et al proposed a reliable HPLC-DAD (High Performance Liquid Chromatography and Diode Array Detection) for identification and quantification of ascorbic acid, and further indicated that high antioxidant activity is due to a large percentage of presence of ascorbic acid.

In recent years Raghu et al (2007) compared ascorbic acid content of the fruits by conventional colorimetric estimation, specific enzymatic method and derivative of dehydroascorbic acid and concluded that 100 g of fresh fruit contain 34-38 mg vitamin C.

The presence and quantity of ascorbic acid in Amla has however, remained a debated issue for a long time.

Revisiting Amla Chemistry:
To elucidate the bioactives responsible for the beneficial effects of Amla, and their contribution towards its antioxidant activity, scientists at Sabinsa Corporation chose to revisit the chemistry of the Indian Gooseberry.

Tannin Chemistry

The research team at Sabinsa Corporation developed a new HPLC method for the characterization and analysis of the various constituents of Amla extract.

The aqueous extract of the fresh fruits of Amla was separated using preparative reverse phase column chromatography, and the different fractions obtained were individually lyophilized and analyzed using various spectroscopic methods.






From the various spectral investigations conducted it was concluded that, the molecule previously reported as emblicanin A is actually β-glucogallin





Similarly, the previously reported 2, 3, 4, 6-bis-(S)-hexahydroxydiphenoyl-2-keto-glucono-lactone (emblicannin B) is in fact mucic acid 1,4-lactone 5-O-gallate

Other molecules identified include gallic acid and mucic acid methyl ester 2-O-gallates and ellagic acid.

The studies summarized above, led the research team at Sabinsa Corporation to believe that β-glucogallin and mucic acid gallates are the predominant active molecules in Amla, and that these molecules are significant contributors to the healthy effects of Amla.


Investigating the ascorbic acid content in Amla fruit extracts:

The fraction corresponding to ascorbic acid peak was isolated by preparative HPLC and evaluated by mass and NMR spectra. It was found that this fraction contained more than one compound which was different from ascorbic acid. It was resolved into four peaks using a modified LC-MS method. In addtion to ascorbic acid the fraction was found to mainly contain mucic acid gallates.

Ascorbic acid content in Amla extracts:

In order to ensure that there was no chemical degradation of any ascorbic acid, the fresh juice of Amla fruits was obtained and processed with optimum care. Various batches of fruits were processed under similar conditions and their ascorbic acid content evaluated.

A variety of Amla extract samples were studied and it showed either complete absence of ascorbic acid or trace amounts to a maximum of 4.0% w/w.

Even though ascorbic acid was not detected, Saberry® did show potential antioxidant activity. This indicated that ascorbic acid is not the most optimal biomarker that reflects the biological potential of Amla. Thus β-glucogallin is a more optimal and relevant biomarker, and reflects the antioxidant potential of Amla, more accurately than ascorbic acid.

For more information : 
Muhammed Majeed, Beena Bhat, Atul N. Jadhav, Jyotish S. Srivastava and Kalyanam Nagabhushanam. Ascorbic Acid and Tannins from Emblica officinalis Gaertn. Fruits ‐A Revisit. J. Agric. Food Chem., 2009, 57, 220‐225

Antioxidant Potential of Saberry® :

Based on scientific evidence, daily antioxidant intake should increase to 3,000 to 5,000 ORAC units per day to reach a significant antioxidant capacity in blood plasma and other tissues. According to the U. S. Department of Agriculture (USDA), current intake is about 1,200 units per day.

Brunswick Laboratory in Wareham, Massachusetts, evaluated the power of Saberry® using state-of-the-art tests. The suite of ORAC assays - ORAC, HORAC, NORAC, SORAC and SOAC – are validated tests to measure broad-spectrum antioxidant power. They are recognized as the premier antioxidant tests available today to the industry, and are used extensively by leading manufacturers.

The ORAC unit is expressed as micromole per gram or liter. The ORAC analysis provides a measure of the scavenging capacity of antioxidants against "peroxyl radical" which is one of the most common reactive oxygen species (ROS) found in the body.

ORAC Values of Saberry™
Assay Units
   ORAChydro(H -ORAC) (µmol TE/100g)
267,800
   ORAClipo (L-ORAC) (µmol TE/100g)
400
   ORACtotal (H-ORAC+ L-ORAC) (µmol TE/100g)
268,200
   HORAC (µmol CAE/100g )
34,500
   NORAC (µmol TE/100g )
90,400
   SOD (k unitsSODeq/100g)
10,200
   SOAC (µmol VitE/100g)
135,100

Saberry® is a leader among water soluble phytonutrients in terms of broad spectrum antioxidant activity.
   
 

Broad spectrum antioxidant activity is based on the values of

 
  • ORACTotal - [hydrophilic (H-ORAC) and lipophilic (L-ORAC) - Peroxyl Radical Absorbance Capacity) expressed as Trolox Equivalent
  • HORAC (Hydroxyl Radical Absorbance Capacity) expressed as Caffeic Acid Equivalent
  • NORAC (Peroxynitrite Radical Absorbance Capacity) expressed as Trolox Equivalent
  • SOAC (Singlet Oxygen Absorbance Capacity) expressed as alpha-tocopherol Equivalent
  • SOD (Superoxide Dismutase equivalent activity, corresponding to Superoxide Radical Absorbance Capacity)

Based on the enhanced antioxidant potential of β-glucogallin over ascorbic acid as evident in the above graphs, and the inconsistent presence of ascorbic acid in Amla in general, the researchers at Sabinsa concluded that it would be pertinent and more accurate to concentrate on the antioxidant potential of β-glucogallin.

Nutraceutical Applications of Saberry® :


Antioxidant Potential:

Saberry® exhibits significant antioxidant activity and is “ORAC Dense”. Literature reports validate the antioxidant potential of Amla in vivo. Amla extract inhibits radiation‐induced lipid peroxidation (LPO) in microsomes, and protects SOD in mitochondria.

For the LPO experiment, Amla extract was added in aqueous solution. The extent of LPO was measured in terms of thiobarbituric acid reactive substances. It was observed that Amla extract acts as a very good antioxidant against γ-radiation induced LPO. Similarly, Amla extract was found to inhibit the damage to antioxidant enzyme SOD in rat liver microsomes. The antioxidant activity of the Amla extract was found to be both dose-and concentration-dependent. The authors concluded that Amla extract being water-soluble, may scavenge the free radicals responsible for initiating lipid peroxidation.

Digestive Aid:

Amla fruit has been traditionally used as a digestive aid in India. It also forms an important constituent of Triphala – an ayurvedic preparation recognized for its role in supporting digestive functions.

Amla is known to improve the stimulation of gastric juices and also support detoxification. 
Amla is also reported to have antibacterial and astringent properties that potentially support the management of infections and help in the healing of ulcers.

Rafatullah (2002) demonstrated the gastroprotective effects of Amla in vivo in rats. Amla extract was found to possess antisecretory, antiulcer, and cytoprotective properties.

Anti-diabetic Potential:

Suryanaraya et al (2004) investigated the beneficial role of Amla extract in diabetes induced complications. Aldose reductase (AR) has been a drug target because of its involvement in the development of secondary complications of diabetes, including cataract. Amla extract inhibited rat lens AR and recombinant human AR with IC50 values 0.72 and 0.88 mg/ml respectively.

In-house studies on β-glucogallin showed an IC50 value of 53.7 µg/ml for the inhibition of aldose reductase, in rat lens.

Rao et al (2005) reported the efficacy of Amla extract in relieving oxidative stress, and improving glucose metabolism in diabetic rats. Yokozawa et al (2007) demonstrated that administration of Amla extract helps in the management of age-related renal dysfunction in aging animal models, through inhibiting oxidative stress and inflammatory pathways. Renal dysfunction is a common secondary complication in diabetes.

Hepatoprotectant Potential Of Amla

Amla is used in Indian system of medicine for the treatment of liver ailments. Emblica officinalis has the potential to suppress carcinogen‐induced response in rat liver.

The research conducted at Amala Cancer Research Centre in Kerala, India, has found that an extract of Phyllanthus emblicasignificantly inhibited hepato‐carcinogenesis induced by N-nitrosodiethylamine (NDEA) in experimental animals.

Fibrosis of the liver is a state of complicated end stage alteration of structure and function due to different etiologies. There is no established therapy, and the treatment options require long term administration of putative anti‐fibrotics which must be free of side effects.

Emblica officinalis (fruit) exract reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Improvement in liver function was observed by measuring the levels of aspartate aminotransaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin in serum.

Dosage form and Suggested use level:

Saberry® can be used in the form of capsules, tablets or incorporated in functional foods

Saberry®, being water soluble, can also be conveniently incorporated into various beverages. Thus Saberry™ finds interesting applications in health and wellness beverages, citrus fruit juices, sports drinks etc.

Depending on the intended use, we suggest that Saberry® be used at levels ranging from 200 mg to 1000 mg per day in two divided doses.

Saberry® also finds interesting applications in Fruit juices, Citrus-based beverages, Noodle flavor packs, Dusting flavors for products like chips, wafers, cashewnuts, peanuts etc.

Cosmeceutical Applications of Saberry® :
Saberry® can find useful applications in:

Several theories have been proposed to account for age‐related changes in cell functioning and physiological capability.

The "Free Radical Theory of Aging" was propounded several decades ago by Prof. Harman (1956). Recent scientific evidence validates the supportive role of dietary interventions in healthy aging and longevity.

Free radicals are molecules with one or more unpaired electrons; they seek stability by taking electrons from other molecules (a process called oxidation). As a consequence, free radicals damage the molecules from which they take electrons, leading to cell damage, impaired functioning, and even cell death. The prime molecules in the body that are damaged by free radicals are DNA, lipids, and proteins.

A bioactive that has the capacity to scavenge the free radicals formed, is regarded as an antioxidant.

Saberry® is proven to have a significant antioxidant potential.

Amla extract offers broad-spectrum protection against heavy metals

Amla extract helps protect the skin from the damaging effects of free radicals and heavy metal‐induced oxidative stress.

Several animal studies have shown that Amla can help prevent a toxic build-up of heavy metals caused by frequent exposure to metals like aluminium, lead and nickel. When vitamin C alone was used, equivalent to that found in Amla fruit only partial protection from heavy metals was provided.

A standardized extract of Phyllanthus emblica was found to have a long lasting and broad spectrum antioxidant activity. The product has no pro‐oxidation activity induced by iron and/or copper because of its iron and copper chelating ability. These play a significant role in the use of Amla extract in anti-aging formulations.

Amla has even been proven to almost completely prevent DNA and cell damage from arsenic poisoning.

In laboratory tests done on animals it was also shown to prevent cellular damage resulting from lead, aluminum, nickel, cadmium, and chromium toxicity.

Amla extract and Matrix Metalloproteinases (MMPs)

With increasing age, collagen synthesis becomes lower and MMP-1 levels become higher in naturally aged human skin, and these alterations cause changes such as skin wrinkling and loss of elasticity (Varani et al 2000). Therefore, control of collagen metabolism may be useful for a variety of therapeutic and cosmetic applications.

Fujii et al (2008) demonstrated that amla extract increased procollagen type I C-peptide (PIP) and tissue inhibitor of metalloproteinase-1 (TIMP-1) production, and decreased MMP-1 production, concomitant with elevated mitochondrial activity in the fibroblast, in a concentration dependent manner.

The above study has shown that Amla extract helps elevate the mitochondrial activity of human skin fibroblasts and promotes production of procollagen and has a number of potential cosmetic applications, particularly as an anti-aging ingredient.

 

Sun Care And After Sun Care Formulations
Saberry® was also found to possess significant potential as a UVA and UVB protectant.

 
Photoprotective Activity Against UVA And UVB Rays Saberry™
Melanin Inhibition in B16 F1 Cells IC50 (µg/ml) UV
12 µg/ml
B protection in Swiss 3T3 Cells EC50 (µg/ml) 
(effective concentration for 50% UV protection)
41.2 µg/ml
UV A protection in Swiss 3T3 Cells EC50 (µg/ml)
(effective concentration for 50% UV protection)
14 µg/ml

With the added advantage of its potential antioxidant activity, Saberry® can help in the management of sunlight induced photodamage.
Hair Care Applications

 

Amla has a long tradition in being used for improving the health of hair and scalp. It is widely used in hair care preparations as a natural hair conditioner.

 

The most commonly implicated androgen in hair loss is dihydrotestosterone (DHT), which is a very potent form of testosterone. It is generated in the body by the conversion of testosterone by the enzyme 5-alpha reductase. It stands to reason that if we could decrease the amount of this enzyme, 5-alpha reductase, in the blood or in the hair follicles, less testosterone would be converted to DHT, and therefore DHT levels would be lower. Inhibitors of 5-alpha reductase thus help in hair fall management.

Saberry® was found to exhibit 5-alpha reductase inhibitory activity (about 80% inhibition at a concentration of 250 µg/ml), validating its potential applications in hair care products.

Dosage form and suggested use level:

Saberry® can be used in the form of capsules or tablets for nutricosmetic applications. For topical application it can be conveniently used in the form of creams, sprays, serums, gels and lotions.

Saberry® be used at levels of 0.2% to 1.0% w/w in topical formulations.

Saberry® finds useful application in the following formulations:

  • Anti-aging Creams & Lotions

  • Skin-lightening Creams & Lotions

  • Sun Care & After Sun Care Creams & Lotions